![]() In a syngeneic model of epithelial cancer, we found that 7 days of immunotherapy (TLR9 agonist and checkpoint blockade), prior to thermal ablation, reduced macrophages and myeloid-derived suppressor cells and enhanced IFN-γ–producing CD8 + T cells, the M1 macrophage fraction, and PD-L1 expression on CD45 + cells. Thermal ablation is an appealing modality to pair with such protocols, as tumors can be rapidly debulked (cell death occurring within minutes to hours), tumor antigens can be released locally, and treatment can be conducted and repeated without the concerns of radiation-based therapies. ![]() ![]() Pairing immunotherapy with such focal treatments is particularly attractive however, there is emerging evidence that focal therapy can have a positive or negative impact on the efficacy of immunotherapy. Focal therapies play an important role in the treatment of cancers where palliation is desired, local control is needed, or surgical resection is not feasible.
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